Product Category:
Human Adenovirus Type5 (dE1/E3) expressing Aryl-hydrocarbon Receptor Nuclear Translocator 2 (ARNT2) under CMV promoter.
Description:
Aryl-hydrocarbon Receptor Nuclear Translocator 2, pre-made adenovirus, ready to ship and ready to use format.
Gene Name:
Aryl-hydrocarbon Receptor Nuclear Translocator 2
ACCN:
BC036099
Gene ID:
9915
GI Number:
23271920
Fusion Tag:
No
Promoter:
CMV
Storage Buffer:
DMEM with 2.5% BSA, 2.5% glycerol
Background:
AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
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