serum, plasma, tissue homogenates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
403976
UniProt ID:
Q28268
Components:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables IkappaB kinase activity and protein phosphatase binding activity. Involved in canonical NF-kappaB signal transduction; cell surface receptor signaling pathway; and peptidyl-serine phosphorylation. Acts upstream of or within B cell homeostasis; positive regulation of cation channel activity; and positive regulation of sodium ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex and IkappaB kinase complex. Is expressed in several structures, including cerebral cortex; genitourinary system; heart; and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta).
