HIF1-A; MOP1; PASD8; Basic Helix-Loop-Helix Transcription Factor; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78
Species:
Rat
Sample type:
tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Experimental method:
Sandwich
Shelf life:
12 months
Gene ID:
29560
UniProt ID:
O35800
Component:
1. Pre-coated, ready to use 96-well strip plate 1
2. Plate sealer for 96 wells 2
3. Standard 2
4. Diluents buffer: 1×45 mL
5. Detection Reagent A: 1×120 μL
6. Detection Reagent B: 1×120 μL
7. TMB Substrate: 1×9 mL
8. Stop Solution: 1×6 mL
9. Wash Buffer (30× concentrate): 1×20 mL
Background
Enables sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to decreased oxygen levels; positive regulation of angiogenesis; and regulation of biosynthetic process. Located in nucleus. Used to study acute kidney failure; cerebrovascular disease (multiple); diabetic retinopathy; and hepatocellular carcinoma. Biomarker of several diseases, including artery disease (multiple); bladder neck obstruction; bronchopulmonary dysplasia; ischemia (multiple); and kidney failure (multiple). Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; myocardial infarction; prostate cancer; and type 2 diabetes mellitus. Orthologous to human HIF1A (hypoxia inducible factor 1 subunit alpha).
